5-Ureidohydantoin (ALLANTOIN)
Global Regulation Summary
Overview of current status across major international markets.
Detailed Regional Status
| Region | Status | Max Conc. | Conditions | Source |
|---|---|---|---|---|
| πͺπΊ EU | Unknown | - | - | Official β |
| πΊπΈ USA | Unknown | - | - | Official β |
| π―π΅ Japan | Unknown | - | - | Official β |
| π°π· Korea | Unknown | - | - | Official β |
| π¬π§ UK | Unknown | - | - | Official β |
πΏ Natural Sources
Found in comfrey plant root (Symphytum officinale) at 0.7-2.5% concentration (HPLC analysis shows 15.14-36.46 mg/g dry weight in commercial samples). Also present in urine of most mammals. Wheat germ, soybean, and other botanical sources contain trace amounts.
π How It's Made
Synthetically produced for cosmetic use via three methods: oxidation of uric acid, reaction of dichloroacetic acid and urea, or direct condensation of glyoxylic acid and urea (most common). Chemically synthesized bulk allantoin is chemically equivalent to natural allantoin. First synthesized from uric acid in 1837 by German chemists Friedrich WΓΆhler and Justus Liebig.
π Uses in Cosmetics
FDA-listed as effective and safe at 0.1-2% for skin protection. Typical use levels: 0.2-2%. Found in moisturizers, anti-acne products, sun care, toothpaste, mouthwash, shampoos, and after-sun products. Promotes wound healing, reduces inflammation, and enhances skin moisture retention.
π¬ Other Applications
Used in pharmaceutical ointments for wound healing, ulcer treatment, and oral hygiene products. Applied in veterinary medicine for skin conditions. Also found in toothpaste and mouthwash for its antibacterial and soothing properties on oral mucosa.
π‘ Fun Facts
- β’ First isolated in 1800 by Italian physician Michele Francesco Buniva and French chemist Louis Nicolas Vauquelin, who mistakenly believed it was in amniotic fluid
- β’ Named 'l'acide allantoique' in 1821 by Jean Louis Lassaigne after finding it in allantois fluid
- β’ In humans and higher apes, the metabolic pathway to convert uric acid to allantoin is absent, so uric acid is excreted instead - making humans unable to naturally produce allantoin internally
Frequently Asked Questions
What is ALLANTOIN used for in cosmetics?
ALLANTOIN is primarily used for skin conditioning in cosmetic products. It also serves as soothing, anti-irritant. The ingredient is commonly found in moisturizers, lotions, and creams.
Which countries regulate ALLANTOIN?
ALLANTOIN is approved for cosmetic use in all major markets: , with no significant restrictions.
Where can I find official regulation information about ALLANTOIN?
Official information about ALLANTOIN regulations can be found on government websites: EU CosIng database, US FDA Cosmetics page, Japan MHLW cosmetics standards, UK Government cosmetics guidance, and Korea MFDS. Always verify regulatory status with these official sources before making formulation decisions.
Disclaimer
The information on this website is for educational and informational purposes only and is not intended as medical advice. While we strive for accuracy based on official government databases, cosmetic regulations change frequently. Always consult with a qualified professional or refer to the latest official regulatory documents for compliance. We are not responsible for any actions taken based on the information provided here.