Provitamin B5 (PANTHENOL)
Global Regulation Summary
Overview of current status across major international markets.
Detailed Regional Status
| Region | Status | Max Conc. | Conditions | Source |
|---|---|---|---|---|
| πͺπΊ EU | Unknown | - | - | Official β |
| πΊπΈ USA | Unknown | - | - | Official β |
| π―π΅ Japan | Unknown | - | - | Official β |
| π°π· Korea | Unknown | - | - | Official β |
| π¬π§ UK | Unknown | - | - | Official β |
πΏ Natural Sources
Pantothenic acid (parent compound) is found in most plant and animal foods including liver, kidney, wheat germ, royal jelly, peanuts, spinach, cheese, peas, eggs, beef, chicken, mushrooms, tuna, sunflower seeds, avocado, and whole grains like oats and brown rice. Name derived from Greek 'pantothen' meaning 'from everywhere'.
π How It's Made
Synthesized by condensing D-pantolactone with 3-aminopropanol, yielding D-panthenol (the biologically active form). Chemical structure elucidated in 1938 by Williams; synthesis method established in 1939. Only D-panthenol (dexpanthenol) is biologically active; DL-panthenol is a racemic mixture where only the D portion converts to Vitamin B5.
π Uses in Cosmetics
Used at 0.5-5% concentration (CIR deems safe at 1-5%). Hair care: 0.1-1%. Supplied as highly purified (>98%) viscous liquid (75-100% active) or powder. Provides humectant and moisturizing benefits, improves skin barrier function, and enhances hair elasticity and shine.
π¬ Other Applications
Therapeutic agent in pharmaceutical ointments for treating burns, anal fissures, conjunctival inflammation, and wound healing. Swiss company Hoffmann-La Roche identified its regenerative properties in the 1940s for treating severe skin injuries from WWII burns. Used in products like Bepanthen wound healing ointment.
π‘ Fun Facts
- β’ Pantothenic acid was first described by Williams in 1933 and named from Greek 'pantothen' (from everywhere) because it was found in virtually all biological materials
- β’ Swiss scientists at Hoffmann-La Roche in the 1940s discovered panthenol's wound-healing properties while treating WWII burn victims, leading to the development of Pantene haircare
- β’ Only the D-form (dexpanthenol) is biologically active - the L-form in DL-panthenol provides only sensory benefits
Frequently Asked Questions
What is PANTHENOL used for in cosmetics?
PANTHENOL is primarily used for skin conditioning in cosmetic products. It also serves as humectant, hair conditioning. The ingredient is commonly found in moisturizers, lotions, and creams.
Which countries regulate PANTHENOL?
PANTHENOL is approved for cosmetic use in all major markets: , with no significant restrictions.
Where can I find official regulation information about PANTHENOL?
Official information about PANTHENOL regulations can be found on government websites: EU CosIng database, US FDA Cosmetics page, Japan MHLW cosmetics standards, UK Government cosmetics guidance, and Korea MFDS. Always verify regulatory status with these official sources before making formulation decisions.
Disclaimer
The information on this website is for educational and informational purposes only and is not intended as medical advice. While we strive for accuracy based on official government databases, cosmetic regulations change frequently. Always consult with a qualified professional or refer to the latest official regulatory documents for compliance. We are not responsible for any actions taken based on the information provided here.